Natural Killer Cell Tolerance: Control by Self or Self-Control?
نویسندگان
چکیده
منابع مشابه
Natural killer cell tolerance: control by self or self-control?
A major challenge for the immune system is to control pathogens and stressed cells, such as infected or tumors cells, while sparing healthy self-cells. To achieve this tolerance to self, immune cells must recognize and differentiate "self" versus "nonself" and "self" versus "altered self." In the absence of self-tolerance, cells of the adaptive immune system attack healthy cells and cause autoi...
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Natural killer (NK) cells are regulated by numerous stimulatory and inhibitory receptors that recognize various classes of cell surface ligands, some of which are expressed by normal healthy cells. We review two key issues in NK cell biology. How do NK cells achieve tolerance to healthy self-cells, despite great potential variability in inhibitory and stimulatory receptor engagement? How is the...
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Natural killer cells express inhibitory receptors specific for polymorphic MHC molecules, which enables them to mediate "missing self recognition", the capacity to attack self cells that extinguish expression of MHC class I molecules. A key question is: how are NK cells rendered self-tolerant? It was proposed that all NK cells express at least one inhibitory receptor specific for self MHC, but ...
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The immune system is a built-in defense mechanism, which continuously monitors invading pathogens in all living organisms and keeps them physiologically fit. Both the innate and adaptive arms of the immune system are involved in this process of tolerating ‘self’ and targeting ‘non-self’ cells and their respective cellular antigens. Innate immunity is the first line of host defense and it is spe...
متن کاملSelf-Association of an Activating Natural Killer Cell Receptor, KIR2DS1
As a major component of the innate immune system, natural killer cells are responsible for activating the cytolytic killing of certain pathogen-infected or tumor cells. The self-recognition of natural killer cells is achieved in part by the killer cell immunoglobulin-like receptors (KIRs) protein family. In the current study, using a suite of biophysical methods, we investigate the self-associa...
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ژورنال
عنوان ژورنال: Cold Spring Harbor Perspectives in Biology
سال: 2012
ISSN: 1943-0264
DOI: 10.1101/cshperspect.a007229